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与衰老相关的睡眠和呼吸的改变在素敲击麻醉症小鼠中

Stefano Bastianini¹, Sara Alvente¹, Chiara Berteotti¹

¹Laboratory of Physiological Regulation in Sleeping Mice (PRISM), Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

Journal of sleep research

|July 20, 2024

概括

麻醉症类型-1 (NT1) 是一种睡眠障碍,由素系统损伤引起. 这项研究发现,老化和素缺乏都会显著改变小鼠的睡眠模式和呼吸,而麻醉症的表型会随着年龄的增长而持续.

科学领域:

神经科学是一个神经科学.
睡眠医学睡眠医学
衰老研究研究衰老研究

背景情况:

麻醉症1型 (NT1) 是一种慢性睡眠障碍,与神经激素系统功能障碍有关,通常在年轻成人时出现.
睡眠架构和呼吸模式自然会随着年龄的增长而改变.
了解老化如何影响NT1对于在患者一生中管理这种情况至关重要.

研究的目的:

研究素缺乏和衰老对小鼠的睡眠-清醒模式和呼吸的综合影响.
为了比较年轻和老年小鼠的睡眠表型,素敲击 (KO) 和野生类型 (WT) 的小鼠.

主要方法:

使用脑电图 (EEG) 和肌电图 (EMG) 来记录年龄匹配的年轻 (16周) 和年长 (87周) 雌性KO和WT小鼠的睡眠阶段 (清醒,NREMS,REMS).
评估睡眠期间的呼吸模式,使用囊造影.
分析了睡眠周期的持续时间,频率和呼吸系统参数.

主要成果:

衰老导致清醒程度降低,睡眠碎片化增加,NREMS发作更多,NREMS呼吸暂停减少,不管素水平如何.
与WT小鼠相比,素缺乏 (KO小鼠) 导致了类似触发症的发作,更短的REMS延迟时间,更快的呼吸,并在REMS期间增加了分钟通风.
衰老和素缺乏都独立调节睡眠和呼吸表型,麻醉症表型在老年KO小鼠中很大程度上保留.

结论:

素缺乏和衰老显著影响小鼠的睡眠和呼吸模式.
在雌性小鼠中,麻醉症的表型在整个衰老过程中基本保持不变.
这些发现突显了素系统,衰老和睡眠调节之间的复杂相互作用.

关键词:

呼吸暂停 (apnea) 是一种这种类型的 cataplexy.年长的老人老年人老年人.催眠主义者催眠主义者动物动物动物

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