在体外抗菌活性的多西环素,米诺环素和tigecycline对Mycobacterium复合体:一个元分析研究研究
Weihe Zhang1, Lingling Dong1, Peixuan Men2
1National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149, China.
Diagnostic microbiology and infectious disease
|July 20, 2024
概括
菌根综合体 (MABC) 感染对多西环素和米诺环素具有很高的耐药性. 提格环素在体外对MABC表现出更大的活性,这表明它是这些具有挑战性的感染的潜在治疗选择.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 菌根综合体 (MABC) 感染是一个日益严重的全球健康问题.
- 由于抗生素耐药率高,这些感染非常难以治疗.
- 目前对MABC感染的治疗选择有效性有限.
研究的目的:
- 评估多克西环素 (DOX),米诺环素 (MIN) 和tigecycline (TGC) 与MABC的临床分离物的体外活性.
- 为了确定MABC对这些四环素的综合体体内耐药率.
主要方法:
- 通过使用PubMed/MEDLINE,Web of Science和Embase进行了相关文献的系统审查.
- 包括遵守临床和实验室标准研究所 (CLSI) 药物敏感性测试指南的研究.
- 使用随机效应模型计算聚合抵抗率并评估异质性.
主要成果:
- 在8μg/mL断点时,MABC对多西环林和米诺环林的聚合耐药率很高 (分别为93.0%和87.2%).
- 提格环素表现出较低的聚合耐药率,在2,4和8μg/mL的断点之间从2.5%到16.8%不等.
- 二十六个出版物被纳入了元分析.
结论:
- 在实验室中MABC对多西环素和米诺环素的高耐药性限制了它们的临床实用性.
- 提格环素在体外显示出对MABC分离物的有希望的敏感性.
- 提格环素代表了管理MABC感染的潜在治疗选择.
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