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瘤微环境的进步:3D生物打印的应用和挑战

Yingying Dong¹, Xue Zhou², Yunyi Ding³

¹The First School of Climical Medicine of Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Biochemical and biophysical research communications

|July 20, 2024

概括

3D生物打印为瘤微环境 (TME) 建模提供了一种变革性的方法,克服了传统方法的局限性. 这项技术使得精确的,个性化的癌症研究和药物开发成为可能,从而推进了瘤学研究.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
生物材料科学生物材料科学

背景情况:

瘤微环境 (TME) 在癌症的进展和治疗中至关重要.
传统的研究方法面临着诸如高成本,可复制性差,建模成功率低等挑战.
准确的TME建模对于推进癌症研究和个性化医学至关重要.

研究的目的:

探索3D生物打印在TME建模中的进步和应用.
讨论用于癌症研究3D生物打印的方法,生物材料和瘤模型.
为了解决3D生物打印在瘤学中的当前挑战和未来潜力.

主要方法:

审查用于TME建模的尖端3D生物打印技术.
分析各种生物材料及其适用于创建3D瘤模型的适用性.
检查各种3D生物打印策略,以精确控制细胞和矩阵.

主要成果:

3D生物打印可以在TME模型中精确控制细胞分布和矩阵组成.
该技术促进了癌细胞的现实3D培养,桥梁体外和体内研究.
数字设计集成允许个性化研究,具有高度的实验灵活性.

结论:

3D生物打印在准确建模TME方面取得了重大进展.
尽管存在物质限制和可重复性等挑战,但它对个性化医学和药物发现有巨大的潜力.
这项技术将通过实现高分辨率的有机体构造和瘤模拟来彻底改变瘤学研究.

关键词:

3D生物打印技术的使用.癌症癌症癌症癌症瘤的微环境瘤的微环境瘤模型瘤模型

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