在大米中增强耐药粉:细菌的胰岛素作为代谢和葡萄糖吸收调节器
Ravishankar Palanisamy1, Satheesh Kumar Subramanian2, Samuel Kuwaku Asiedu3
1Department of Neurosurgery, McGill University, Montreal, Quebec H3A 0G4, Canada; Department of Biotechnology, Periyar University, Salem, Tamil Nadu 636011, India; Rayakis, Energy and Environmental Consultancy, Periyar Street, Salem, Tamil Nadu 636 001, India.
杆菌PE通过抑制粉代谢酶和改变基因表达,提高了米的质量. 这种微生物治疗显示出管理II型糖尿病和减少胰岛素依赖的潜力.
科学领域:
- 微生物学 微生物学
- 生物化学 生化学
- 遗传学 是一个遗传学.
背景情况:
- 米是一种主食,它的粉代谢对能量至关重要.
- 二型糖尿病管理通常涉及控制碳水化合物消化和吸收.
- 微生物干预提供了新的方法来调节食物特性和生理反应.
研究的目的:
- 为了研究 Bacillus stercoris PSSR12 (B. stercoris PE) 对米粉质量的影响.
- 评估B. stercoris PE.对关键碳水化合物代谢酶的体外抑制.
- 分析B. stercoris PE对大米和脂肪细胞中粉合成和葡萄糖吸收基因的影响.
主要方法:
- 16s rRNA测序用于细菌识别.
- 用于酶和胰岛素合成验证的SDS-PAGE和FTIR.
- 在体外酶抑制试验 (α-氨基酶,α-葡萄糖酶).
- 对粉合成 (RAmy1a,GBSSIa,SBEIIa,SBEIIb) 和葡萄糖载体 (GLUT1,GLUT4) 基因进行定量mRNA分析.
- 在3T3-L1脂肪细胞中进行分析.
主要成果:
- B. stercoris PE在体外证明了各种水品种中α-氨酶和α-葡萄糖酶的抑制.
- 治疗引起了粉超结构刚性的变化以及粉合成基因的分子变化.
- 在经过处理的米品种中观察到增强的葡萄糖载体基因表达 (GLUT1,GLUT4).
- B. stercoris PE的应用改善了谷物的整体质量.
结论:
- 菌PE具有调节粉代谢有益的特性.
- 这种微生物处理可以提高米粒质量,并抑制与碳水化合物消化相关的酶.
- 这些发现表明B. stercoris PE在开发用于糖尿病管理和减少胰岛素依赖的功能性食品方面可能发挥作用.
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