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双极性和精神分裂性谱系障碍中的可复制肠道微生物特征:一个全基因组研究

Magdalini Ioannou¹, Jenny Borkent², Sergio Andreu-Sánchez³

¹University of Groningen and University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands; University of Groningen and University Medical Center Groningen, Department of Biomedical Sciences, Groningen, the Netherlands.

Brain, behavior, and immunity

|July 20, 2024

概括

肠道微生物组的改变与双相情感障碍 (BD) 和精神分裂症谱系障碍 (SSD) 有关. 特定的细菌平衡,包括Lachnoclostridium和Eggerthella,显示出诊断BD/SSD和预测治疗反应的潜力.

科学领域:

微生物组研究的研究.
精神病学遗传学精神病学遗传学
转基因组学是指转基因组学.

背景情况:

在双相情感障碍 (BD) 和精神分裂症谱系障碍 (SSD) 中,肠道微生物组失调经常被报告.
关于与这些精神疾病相关的特定细菌种群存在有限的共识.

研究的目的:

为了识别特定于BD/SSD的可复制肠道微生物特征.
探索微生物特征,症状严重程度和药物使用之间的关联.

主要方法:

在荷兰的BD/SSD患者和健康对照中进行全面的元基因组射击枪测序.
使用两个独立的队列与不同的种群和协议进行验证.
应用CoDaCoRe学习算法来识别细菌平衡.

主要成果:

患者和对照人群之间肠道微生物群β-多样性的显著差异.
在患者中复制Lachnoclostridium和Eggerthella属.
鉴定了两种特定于BD/SSD的细菌平衡,其AUC为0.77,与症状严重程度和抗精神病药物的使用有关.
克莱布西拉和抗精神病药物使用,以及阿纳埃罗马西里巴西勒和使用之间的积极关联.

结论:

微生物平衡提供了一种可重复的方法来识别BD/SSD特定的特征.
在BD/SSD中经常观察到拉科克洛斯特里和埃格特拉菌.
证实了Klebsiella和抗精神病药物之间的确立联系,以及Anaeromassilibacillus和之间的新兴关联.

关键词:

双极性障碍是一种双极性障碍.大脑-肠轴 - 大脑-肠轴胃肠道的微生物群转基因组学是指转基因组学.精神分裂症是一种精神分裂症.精神分裂症频谱和其他精神病障碍.

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