在儿童和青少年重症监护病房幸存者中发展重大精神疾病的风险
Ping-Chung Wu1, Shih-Jen Tsai2, Ya-Mei Bai2
1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal of affective disorders
|July 20, 2024
概括
儿童和青少年重症监护室 (ICU) 的幸存者面临更高的重大精神疾病 (MPD) 风险,包括PTSD和精神分裂症. 这凸显了针对这些易受伤害的年轻患者制定针对性MPD预防策略的必要性.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 儿童和青少年精神病学
- 公共卫生研究 公共卫生研究
背景情况:
- 儿童和青少年心理健康重症监护室 (ICU) 的入院研究不足.
- 关于危急疾病类型如何影响儿科人口中特定精神疾病的数据有限.
研究的目的:
- 调查儿科重症监护室存活率与发展五种主要精神疾病 (MPD) 的风险之间的关联.
- 在儿童ICU幸存者中量化精神分裂症,双相情感障碍 (BD),主要抑郁障碍 (MDD),强迫症 (OCD) 和创伤后应激障碍 (PTSD) 的风险.
主要方法:
- 分析了全国范围的数据集,包括8,704名儿科重症监护室幸存者和87,040名匹配的对照从1996年至2013年.
- 纵向随访以评估五种MPD的发生率.
主要成果:
- 与对照人群相比,儿童重症监护室幸存者对所有五种MPD的风险显著增加.
- 具体危险比率 (HRs) 包括:PTSD (HR=4.67),精神分裂症 (HR=3.19),BD (HR=2.02),强迫症 (HR=1.96) 和MDD (HR=1.68) 在内.
- 患MPD的风险取决于导致ICU入院的危急疾病类型.
结论:
- 儿科重症监护室的幸存者患重大精神疾病的风险要大得多.
- 强调MPD预防策略对于这种高风险儿科患者群体至关重要.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
82
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
82
Post-traumatic Stress Disorder
31
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
31
Stress and Mental Health
96
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
96
Schizophrenia
73
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
73
Attention-Deficit/Hyperactivity Disorder
51
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
51
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
553
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
553


