强大的大脑与精神病中的认知表现及其前相关
Heather Burrell Ward1, Adam Beermann2, Jing Xie2
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Biological psychiatry
|July 20, 2024
概括
连接体全方位的关联研究发现,在早期精神病中,在赛德曼听力持续性表现任务 (ACPT) 上的更好的表现与更高的前额头-体运动连接性有关. 这种大脑行为联系也在后来患上精神病的个体中被发现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 神经认知障碍是精神分裂症的一个标志,在精神病发作之前.
- 之前的连接体全方位关联研究 (CWAS) 显示大脑连接和认知表现之间存在不一致的联系.
- 使用特定的认知任务和人群的精细方法可能会产生更可靠的脑行为关联.
研究的目的:
- 在早期精神病中使用CWAS识别可靠的大脑认知关联.
- 测试这些关联在患精神病风险较高的人群中的概括性.
主要方法:
- 利用赛德曼听力持续表现任务 (ACPT) 进行认知评估.
- 在早期精神病 (HCP-EP) 人类连接组项目数据集 (n=183) 上进行了CWAS.
- 验证了北美Prodrome纵向研究2 (NAPLS2) 数据集中的验证结果 (n=345),包括有风险的个体和对照.
主要成果:
- 早期精神病中的CWAS显示了较高的ACPT表现和前额头-体运动连接性 (p < .005) 之间的显著关联.
- 这种前额头-体运动连接-ACPT性能联系在患有精神病 (n=17) 的高风险个体中得到复制.
- 在没有发展精神病的个人 (非转化者,n=196) 或对照参与者 (n=132) 中,这种关联并不显著.
结论:
- 在精神病和风险人群中,CWAS成功地确定了大脑连接和认知功能之间的可重复联系.
- 这项研究强调了精心挑选的认知测量和研究群体对于强大的CWAS发现的重要性.
- 这些发现促进了我们对精神病谱中认知缺陷的神经支的理解.
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