更大的邻居劣势与胎儿功能大脑网络结构的改变有关
Kevin Michael Cook1, Josepheen De Asis-Cruz1, Chloe Sitrin2
1Developing Brain Institute, Children's National Hospital, Washington, DC.
The Journal of pediatrics
|July 20, 2024
概括
邻居劣势 (ND) 与胎儿大脑发育的改变有关,影响出生前的功能网络. 这表明环境压力因素会影响产前大脑成熟,即使是在健康的怀孕中.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展生物学 发展生物学
背景情况:
- 邻居不利 (ND) 可能会影响胎儿的发育.
- 了解产前暴露的影响对于公共卫生至关重要.
- 在子宫内功能性大脑发育是复杂的,对环境因素敏感.
研究的目的:
- 确定邻居不利 (ND) 与胎儿功能性大脑发育之间的关联.
- 调查社会脆弱性指数 (SVI) 评分如何与胎儿大脑网络结构有关.
主要方法:
- 使用社会脆弱性指数 (SVI) 成绩的观察性研究.
- 分析了来自68个健康怀孕的79个功能磁共振成像 (fMRI) 扫描.
- 使用图表指标和线性混合效应模型对功能性大脑网络结构的表征.
主要成果:
- 较大的ND与功能性大脑网络集成程度较低有关 (较长的特征路径长度,全球效率下降和小世界倾向).
- 在第三个季度,SVI与网络集成之间的关联减少了.
- 小世界倾向在整个怀孕中显示出不断变化的关联,在第三个三个月左右逆转.
结论:
- 直接证据将邻居不利 (ND) 与胎儿功能性大脑成熟的改变联系起来.
- 邻里环境压力因素与产前大脑发育的改变有关.
- 这些发现强调了考虑到胎儿神经发育中的环境因素的重要性.
更多相关视频
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
8.3K
05:44Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
549
相关概念视频
Neurulation
41.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.8K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Attention-Deficit/Hyperactivity Disorder
51
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
51
