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相关概念视频

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

414
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
414
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.4K
Drug Delivery: Overview01:16

Drug Delivery: Overview

285
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
285
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

192
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
192
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

253
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
253

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相关实验视频

Updated: Jun 20, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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基于离子液体的配方方法,用于增强跨粘膜药物输送.

Omar Khan1, Rohit Bhawale1, Ravindra Vasave1

  • 1Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.

Drug discovery today
|July 20, 2024
PubMed
概括

离子液体 (ILs) 通过提高粘膜表面的可溶性和透性来增强药物输送. 这些可适应的化合物为制药应用提供受控释放和长期保留.

关键词:
在水中溶解度水溶性.生物相容性 生物相容性离子液体是一种离子液体.粘膜膜的 粘膜的 粘膜透增强剂是一种透增强剂.药物通过粘膜传递.

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学

背景情况:

  • 离子液体 (ILs) 为先进的制药应用提供独特的调节性质.
  • 传统的药物输送面临着诸如溶解性,透性和疗效差等挑战,特别是在局部和跨粘膜系统中.

研究的目的:

  • 将离子液体分类并审查它们在增强跨粘膜药物递送中的作用.
  • 探索IL如何改善活性药物成分 (API) 的溶解性和透性.
  • 讨论ILs在粘液调节中的潜力,以改善细胞运输和控制药物释放.

主要方法:

  • 各种离子液体的分类.
  • 审查表明ILs对药物溶解性和透性的影响的研究.
  • 分析ILs对粘液特性和药物保留时间的影响.

主要成果:

  • 离子液有效地提高了API的可溶性和透性.
  • ILs通过暂时的粘液调节和增强的细胞运输来促进受控的药物释放.
  • 通过使用基于IL的配方,在各种粘膜表面实现了长时间的药物保留.

结论:

  • 离子液体是有希望的化合物类别,可以克服粘膜药物输送的局限性.
  • 基于IL的配方为开发先进的局部和跨粘膜药物递送系统提供了巨大的潜力.
  • 未来的研究应该专注于进一步探索和优化IL在制药药物输送中的应用.