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Updated: Jun 20, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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3D基因组分析揭示了由复杂的结构变化引起的新型增强器劫持,这些变化驱动着基因过度表达

Katelyn L Mortenson1, Courtney Dawes2, Emily R Wilson1

  • 1Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Nature communications
|July 20, 2024
PubMed
概括

科学家们开发了高活性促进体相互作用 (HAPI) 分析,以检测癌症中的增强器劫持. 这种3D基因组学方法揭示了像MYC这样的瘤基因是如何被劫持增强剂激活的,即使是在复杂的染色体外DNA上.

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