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ATM抑制通过激活STING信号和增强MHC I类增强免疫疗法

Chunya Li1, Boyu Wang2, Jingyao Tu1

  • 1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cell death & disease
|July 20, 2024
PubMed
概括

向DNA损伤反应 (DDR) 通过ATAXIA telangiectasia突变 (ATM) 抑制可以增强抗瘤免疫力. 抑制ATM可以提高结肠直肠癌 (CRC) 细胞的免疫反应,预测放射治疗和免疫治疗的益处.

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