通过在肥胖儿童中补充胰岛素来增强肠道微生物群和微生物功能
Chonnikant Visuthranukul1, Sira Sriswasdi2,3, Surapun Tepaamorndech4
1Center of Excellence in Pediatric Nutrition, Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. chonnikant.v@chula.ac.th.
International journal of obesity (2005)
|July 20, 2024
概括
胰岛素补充剂改善了肥胖儿童的肠道微生物群多样性和有益细菌. 这种益生菌干预表明,它有望恢复肠道平衡,改善儿童肥胖的健康结果.
科学领域:
- 微生物组研究的研究.
- 儿童营养学 儿童营养学
- 代谢健康 代谢健康
背景情况:
- 肠道失调症会加剧肥胖引起的全身炎症.
- 益生菌胰岛素可以逆转代谢异常,改善肥胖.
- 了解胰岛素对肥胖儿童肠道微生物群的影响至关重要.
研究的目的:
- 确定胰岛素补充剂是否能改善肥胖儿童的肠道微生物群和微生物功能通路.
- 评估胰岛素对肠道细菌多样性和特定微生物群体的影响.
- 评估微生物群变化与临床结果之间的相关性.
主要方法:
- 随机,双盲,安慰剂控制的研究.
- 143名患有肥胖症的儿童 (7-15岁) 接受了胰岛素,麦芽素或饮食建议6个月.
- 通过16SrRNA测序和功能通路推断进行肠道微生物组分析.
主要成果:
- 胰岛素显著增加了肠道细菌的α-多样性.
- 胰岛素补充剂增强了有益细菌,包括Bifidobacterium和丁酸盐生产者.
- 与蛋白质酶和 рибофлавин代谢相关的功能途径被胰岛素改变,与临床结果相关.
结论:
- 胰岛素补充剂有效地促进肠道细菌的多样性,并纠正肥胖儿童的失生症.
- 胰岛素调节肠道微生物的功能通路,表明有益的宿主微生物相互作用.
- 胰岛素是恢复儿童肥胖时肠道微生物群平衡的潜在治疗策略.
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