了解左心房附属体对心房流量的作用
Ahmad Bshennaty1, Brennan J Vogl1, Alessandra Maria Bavo2
1Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.
概括
在心房动 (AF) 患者中,左心房尾 (LAA) 排除改变了左心房 (LA) 血流动力学. 这种程序会影响流动模式,可能会影响中风风险和AF管理中的治疗疗效.
科学领域:
- 心血管科学 心血管科学
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 左心房尾 (LAA) 阻塞是心房动 (AF) 患者的治疗选择,这些患者有高风险的中风和出血.
- 对于LAA的精确生理作用仍然不完全理解,需要进一步研究其对心脏功能的影响.
研究的目的:
- 为了研究LAA排除在患有心房的患者中的血液动力学影响.
- 评估LAA排除程序后左心房 (LA) 流动动态的变化.
主要方法:
- 计算流体动力学 (CFD) 模拟被用于分析9名AF患者的LA中的血流.
- 在LAA排除之前和之后进行了模拟,检查了LA速度,时间平均墙面剪切应力 (TAWSS),振荡剪切指数 (OSI),相对停留时间 (RRT) 和LA压力等参数.
主要成果:
- 排除LAA导致TAWSS (1.82 ± 1.85 Pa至1.27 ± 0.96 Pa,p < 0.05) 的显著下降,以及低幅度速度的减少.
- 相反,OSI (0.16 ± 0.10 到 0.17 ± 0.10,p < 0.05),RRT (1.87 ± 1.84 Pa−1 到 2.11 ± 1.78 Pa−1,p < 0.05) 和LA压力 (-19.2 ± 6.8 mmHg 到 -15.3 ± 8.3 mmHg,p < 0.05) 略有增加.
结论:
- 排斥LAA与左心房血液动力学的可测量变化有关.
- 需要进一步的研究,以充分理解AF患者观察到的这些血液动力学变化的临床意义.
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