精神分裂症患者的COVID-19死亡率增加:巴西的一项回顾性研究
Diogo Fernando Bornancin Costa1, Paula Rossignoli2, Deise Regina Sprada Pontarolli2
1Post Graduation Program of Internal Medicine and Health Sciences, Federal University of Paraná (UFPR), Curitiba, Brazil.
Schizophrenia research
|July 21, 2024
概括
巴西的精神分裂症患者面临COVID-19死亡风险的两倍以上. 对于年轻的患者和肥胖患者来说,这种风险明显更高,凸显了护理方面的差异.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 在低收入和中等收入国家,对于精神分裂症患者的COVID-19死亡风险存在有限的研究.
- 精神分裂症是一种严重的精神障碍,影响全球数百万人.
- 了解特定的人口风险对于有针对性的公共卫生干预至关重要.
研究的目的:
- 在巴西南部州的精神分裂症患者中确定COVID-19死亡风险 (标准化死亡率 - SMR).
- 为了调查年龄,性别,肥胖和克洛扎宾使用对这一队列中的COVID-19死亡率的影响.
- 将精神分裂症患者的COVID-19死亡率与普通人口进行比较,并评估肥胖的作用.
主要方法:
- 追溯队列研究将精神分裂症患者数据库 (n=20,417) 与巴西死亡信息系统 (2020-2021) 联系起来.
- 按年龄组和性别计算标准化死亡率 (SMR).
- 后勤回归分析以评估克洛扎宾对COVID-19死亡率的影响,控制共变量.
- 二次分析比较肥胖和不肥胖个体的死亡率.
主要成果:
- 与普通人群相比,精神分裂症患者死于COVID-19的风险是两倍以上 (SMR=2.21).
- 这种风险在16-29岁的精神分裂症患者中是十倍以上的 (SMR=10.18).
- 在精神分裂症队列中,肥胖几乎使COVID-19死亡风险增加了一倍 (OR=1.89). 克洛沙平没有显著的保护性或风险效应.
结论:
- 巴西的精神分裂症患者面临着显著增加的COVID-19过早死亡风险.
- 年轻的精神分裂症患者和肥胖患者承担不成比例的COVID-19死亡负担.
- 公共卫生策略必须解决精神分裂症患者,特别是年轻患者和肥胖患者在中等收入国家增加的脆弱性.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
82
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
82
Biological Causes of Schizophrenia
54
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
54
Schizophrenia
73
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
73
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
553
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
553
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Positive Symptoms Schizophrenia: Hallucinations and Delusions
53
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
53


