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Updated: Jun 20, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

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Published on: January 22, 2019

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发现新型因达衍生物作为第二代TRK抑制剂

Qiaohua Qin1, Shuyu Lu1, Zhiqiang Guo1

  • 1Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China.

European journal of medicinal chemistry
|July 21, 2024
PubMed
概括

新的英达TRK抑制剂通过准NTRK基因融合来对抗癌症. 化合物B31对抗耐药突变具有强大的活性,为NTRK融合阳性癌症提供了有前途的治疗策略.

关键词:
这是一种抗癌药物.药物耐药性 药物耐药性 药物耐药性在 Indazole 中使用.基因融合NTRK基因融合转基因抑制剂是TRK抑制剂.

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