失律症是帕金森病的一个突出的特征:基于应用程序的点击测试
Luca Marsili1, Jesus Abanto1, Abhimanyu Mahajan1
1Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.
Journal of the neurological sciences
|July 21, 2024
概括
智能手机应用程序可以通过测量增加的点击变化来检测帕金森病 (PD). 在一年内,PD患者和健康对照人群之间,点击速度没有显著差异.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 数字健康数字健康
背景情况:
- 智能手机应用程序为运动障碍的临床评估提供客观测量.
- 帕金森病 (PD) 是一种影响全球数百万人的运动障碍.
- 早期和准确的PD诊断对于有效的管理至关重要.
研究的目的:
- 为了测试帕金森病患者在一年内与健康对照人群相比,是否表现出增加的敲击变化和减少的敲击速度.
- 评估基于智能手机的点击测试在评估PD进展中的实用性.
- 为了确定PD中的布拉迪基尼西亚可靠的数字生物标志物.
主要方法:
- 在2021-2023年期间,从295名PD患者和62名健康对照 (HC) 收集前性数据.
- 使用定制的智能手机应用程序进行一年间隔的点击测试.
- 测量了点击速度 (点击/秒),点击间隔,可变性 (运动规律性) 和序列效应.
主要成果:
- 在基线,PD患者表现出明显高于HC (26毫秒) 的输入间变化 (CV:37毫秒) (p=0.007).
- 在基线时,PD和HC之间没有观察到输入间隔或输入速度的显著差异.
- 在一年的时间里,只有PD患者的点击速度有所下降 (p=0.036),而点击间的变异性保持不变.
结论:
- 输入间的变化,表明心律失常,是基于应用程序评估帕金森病中的布拉迪基尼西亚的可靠数字标记.
- 使用这种方法进行PD评估时,没有发现点击速度和点击间隔是PD评估的独特特征.
- 基于智能手机的评估显示出对PD运动症状的客观,纵向监测的希望.
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