-葡萄糖共运输体-2抑制剂在因流体过载和心力衰竭而住院的功能受损患者的使用:一项观察性研究
Shi Yun Tan1, Lourdes Ducusin Galang2, Ee Won Leong2,3
1Department of Renal Medicine, Singapore General Hospital, Singapore City, Singapore.
Cardiorenal medicine
|July 21, 2024
概括
在因心力衰竭或液体过载而住院的功能受损患者中,-葡萄糖共运输体-2 抑制剂 (SGLT2is) 的处方较低. 诸如心血管疾病和糖尿病等因素影响SGLT2i的使用,凸显了改善临床实践的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 建议在病和心力衰竭时使用-葡萄糖携带载体-2 抑制剂 (SGLT2is).
- 使用SGLT2is可能会有所不同,这表明临床实践中存在潜在的差距.
研究的目的:
- 为了确定SGLT2i处方在因流体过载或心力衰竭而住院的功能受损患者中的患病率.
- 在这个患者群体中确定与SGLT2i处方相关的因素.
主要方法:
- 这是一项单一中心的观察性研究,对2543名eGFR20-59毫升/分钟/1.73米2的患者进行了观察.
- 从2022年1月至2023年12月期间从电子医疗记录中收集的数据.
- 多变量逻辑回归用于评估与出院时SGLT2i处方相关的因素.
主要成果:
- 在出院时,SGLT2i被处方给了24.8%的患者.
- 处方与心血管疾病,糖尿病,初级诊断,之前使用SGLT2i,使用RAS阻断剂和更高的eGFR相关.
- 年龄较大与SGLT2i处方相反相关.
结论:
- 在因流体过载/心力衰竭而住院的功能受损患者中,SGLT2i在出院时的处方水平低于最佳.
- 高龄和更严重的病与较低的处方率有关.
- 需要进行干预,以增加SGLT2i的使用,并克服临床惯性.
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