细胞癌
Matthew Young1, Francesca Jackson-Spence1, Luis Beltran2
1Barts Cancer Institute, Queen Mary University of London, London, UK.
Lancet (London, England)
|July 21, 2024
概括
最近的细胞癌治疗进展改善了局部和晚期癌的存活率. 新的辅助疗法如勃利祖马布和免疫检查点抑制剂正在改变治疗模式.
科学领域:
- 癌症学
- 泌尿外科
背景情况:
- 治疗细胞癌 (RCC) 的进展显著,改善了患者的存活率.
- 在治疗局部和晚期癌方面,
研究的目的:
- 审查RCC的流行病学,病理学和诊断.
- 讨论当前基于证据的局部转移性RCC的管理策略.
- 突出未来的研究方向和对癌生物标志物的需求.
主要方法:
- 对流行病学数据的审查.
- 对病理发现的分析.
- 目前和新兴治疗策略的证据综合.
- 对临床试验的讨论.
主要成果:
- 辅助疗法,包括pembrolizumab,显示出生存的好处.
- 免疫检查点抑制剂现在是高级RCC的标准治疗方法.
- 风险评估模型有助于对转移性RCC进行分层治疗选择.
结论:
- 目前对细胞癌的治疗策略已经改善了生存结果.
- 布利祖马布代表了对RCC的辅助治疗的突破.
- 持续的研究和生物标志物开发对于个性化癌治疗至关重要.
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