在肝转移患者中重复常规跨动脉化学栓塞的结果
Kamyar Ghabili1, Austin-Marley Windham-Herman2, Menelaos Konstantinidis3
1Department of Radiology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA; Section of Vascular and Interventional Radiology, Department of Radiology and Biomedical imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Annals of hepatology
|July 21, 2024
概括
对于肝转移,建议在考虑不响应患者的替代治疗之前至少进行四次常规的跨动脉化学栓塞 (cTACE) 疗程. 这种方法与神经内分泌瘤,结直肠癌和肺癌的改善生存结果有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 干预性放射学 干预性放射学
- 在瘤学瘤学.
背景情况:
- 传统的跨动脉化学栓塞 (cTACE) 是肝转移的常见治疗方法.
- 对于没有反应的肝转移而言,cTACE疗程的最佳数量尚未确定.
研究的目的:
- 在放弃治疗之前,确定肝转移重复cTACE会话的最佳次数.
- 评估cTACE在患有神经内分泌瘤 (NET),结直肠癌 (CRC) 和肺癌的肝转移患者中的疗效.
主要方法:
- 从2001年到2015年接受cTACE的85名肝转移患者的回顾性分析.
- 使用欧洲肝脏研究协会 (qEASL) 定量标准进行反应评估.
- 对生存结果的评估 (2年,5年,总体) 与cTACE会话的数量相关.
主要成果:
- 30.7%的患者对第一个cTACE会话有反应.
- 在第二次,第三次和第四次cTACE后不响应的病变的响应率分别为33.3%,23%和25%.
- 第四次cTACE会话与改善的2年,5年和整体存活率有关 (p<0.05).
结论:
- 对于NET,CRC和肺癌的肝转移,重复cTACE可以改善患者的生存率.
- 在切换治疗之前,建议在没有反应的肝转移中至少进行四次cTACE疗程.
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