佛罗芬尼科尔核心外复合纳米凝作为口服剂,用于有效治疗细菌性肠炎
Wanhe Luo1, Jinhuan Liu2, Mengdi Zhang1
1Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science and Technology, Tarim University, Alar, Xinjiang 843300, China.
International journal of pharmaceutics
|July 21, 2024
概括
这项研究开发了新的florfenicol核心-shell复合纳米凝用于治疗细菌性肠炎. 这些纳米凝提高了药物的稳定性,向肠道感染,并显示出对大肠杆菌的增强抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 制药科学 制药科学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 一种抗生素佛罗芬尼科尔 (Florfenicol) 受苦和胃酸的降解,限制了其口服疗效.
- 需要有针对性的药物输送系统来增强抗菌活性并改善患者的遵守性.
研究的目的:
- 开发用于口服的florfenicol核心外复合纳米凝.
- 为了改善florfenicol的稳定性,减少苦味,并在肠道中实现有针对性的缓慢释放.
- 加强对大肠杆菌的抗菌活性,并评估生物安全性.
主要方法:
- 佛罗芬尼科尔通过静电相互作用被加载到奇托寡糖化物 (COS) 和pectin核心纳米凝中.
- 这些核心纳米凝被封装在碳素甲基纤维素 (CMCNa) 纳米凝中,使用Ca2+复合.
- 评估了物理化学性质,pH响应,抗菌活性,治疗疗效和生物安全性.
主要成果:
- 优化的配方产生了124.0纳米颗粒直径的纳米凝和高封装效率 (80.5%).
- 核心外纳米凝表现出良好的稳定性,pH响应性和成功的向释放.
- 观察到对大肠杆菌的优良抗菌活性,令人满意的治疗效果和良好的口感.
结论:
- 佛罗芬尼科尔核心外复合纳米凝已成功制备,提供更好的稳定性和有针对性的交付.
- 这些纳米凝显示出通过口服治疗细菌性肠炎的显著潜力,这是由于它们的增强疗效和生物安全性.
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