COVID-19感染的血液蛋白质组学:一个更新
Michal Alexovič1, Tetiana Bondarchuk2, Csilla Uličná3
1Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, 04011, Košice, Slovakia.
概括
本综述探讨了自2022年以来COVID-19患者的血液蛋白质组研究. 它强调了质谱技术,并确定了潜在的蛋白质生物标志物,以改善疾病管理.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 对SARS-CoV-2 (导致COVID-19的病毒) 的分子宿主反应的理解仍然不完整.
- 蛋白质组分析提供了关于COVID-19感染期间宿主分子变化的见解,这对于疾病阶段和管理至关重要.
研究的目的:
- 审查COVID-19患者最近 (自2022年以来) 的血液蛋白质组学研究.
- 为了分析不同的蛋白质组学方法和研究的血液成分.
- 确定和讨论COVID-19潜在的蛋白质生物标志物.
主要方法:
- 专注于基于质谱的血液成分 (血,血清,血小板,红细胞,PBMCs) 的蛋白质组分析.
- 根据样品制备方法对研究进行分类:in-gel,in-solution和在珠子/过器上消化.
- 关于2022年以来发表的科学论文的文献综述.
主要成果:
- 蛋白质组研究揭示了COVID-19疾病各个阶段的分子事件.
- 不同的血液微分会产生不同的蛋白质组形状.
- 采用各种消化技术,每个都有特定的优势.
结论:
- 血液蛋白质组分析对于了解COVID-19的病原体至关重要.
- 识别蛋白质生物标志物可以改善诊断,预后和治疗策略.
- 需要继续进行研究,以充分阐明COVID-19中的宿主蛋白质组.
相关概念视频
01:33Proteomics
7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
02:50Conjugated Proteins
18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K