在怀孕期间短期暴露于空气污染,以及与母亲免疫标志物的关联
C S Yount1, K Scheible2, S W Thurston3
1Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
Environmental research
|July 21, 2024
概括
怀孕期间暴露于二氧化 (NO2) 与母亲的免疫激活有关. 这些影响随着怀孕的进展而加剧,这可能解释了不良分娩结果.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 生殖健康 生殖健康
背景情况:
- 怀孕期间的空气污染与不良结果有关.
- 孕产妇免疫激活是一种拟议的机制.
- 这项研究调查了PM2.5和NO2对母亲免疫标记物的影响.
研究的目的:
- 检查PM2.5和NO2暴露与母体免疫标志物之间的关联.
- 为了确定这些关联是否会在妊娠三季度之间发生变化.
主要方法:
- 纽约罗切斯特的一项妊娠队列研究 (n=290).
- 孕妇的血免疫标志物在怀孕期间测量了多达3次.
- 使用时空模型估计的PM2.5和NO2暴露;用混合效应模型分析的关联.
主要成果:
- 增加的NO2度与TH1,TH2,TH17,调控和恒常组中较高的母体免疫标志物有关.
- NO2与免疫标志物之间的关联在怀孕晚期最强.
- 例如:在怀孕晚期,IL-23增加0.26ppg/ml (95%CI:0.07,0.46) 每7.82ppb的NO2增加.
结论:
- 研究结果表明,暴露于NO2会激活母亲的免疫系统.
- 从怀孕早期到晚期,效应大小的逐渐增加表明免疫功能发生了变化.
- 免疫激活可能会调解空气污染和不良妊娠结果 (如低出生体重) 之间的联系.
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