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侵袭性乳腺癌中的瘤芽,没有特殊类型:与病理预后因素的关联以及2种不同的评分系统的比较

Vinothika Sivamayuran¹, Harshima Disvini Wijesinghe², Roshana Constantine¹

¹Department of Pathology, National Hospital of Sri Lanka, Colombo, Sri Lanka.

International journal of surgical pathology

|July 21, 2024

概括

瘤芽,乳腺癌攻击性的标志物,是普遍存在的,与淋巴结转移相关. 本研究使用×20和×40目标验证了其评估,为资源有限的环境提供了实用方法.

科学领域:

在瘤学瘤学.
病理学病理学病理学

背景情况:

乳腺癌中瘤芽的预后意义尚未得到充分确立.
在资源有限的环境中,使用x20目标,即结直肠癌的标准来评估瘤芽是具有挑战性的.

研究的目的:

为了确定瘤芽在侵袭性乳腺癌-没有特殊类型 (IBC-NST) 的流行率.
调查瘤芽和病理预后因素之间的关联.
评估瘤芽之间的相关性,以×20和×40目标进行评估.

主要方法:

对349个IBC-NST切除标本的分析.
在使用×20和×40目标的入侵前线评估瘤芽.
统计分析包括曼-惠特尼U,克鲁斯卡尔-瓦利斯,奇平方,逻辑回归和皮尔森相关性测试.

主要成果:

瘤芽的流行率为72.5%.
在×20和×40客观评估之间观察到强烈的相关性 (0.958).
高瘤芽与瘤大小,淋巴血管入侵,围神经入侵,淋巴结状况,T阶段和N阶段 (单变分析) 有显著的相关性.
淋巴结的阳性仍然是多变量分析中唯一显著的关联.

结论:

使用×20和×40目标进行瘤芽评估是可靠的,并显示出显著的相关性.
瘤芽与IBC-NST中的淋巴结转移有显著的关联.

关键词:

乳腺癌,乳腺癌.病理参数病理参数瘤的芽是因为瘤芽.

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