神经递质系统在终身早泄的男性中可能的病理生理学作用:一个范围审查
Joost J van Raaij1,2,3, Ege Can Serefoglu4, Thérèse A M J van Amelsvoort3
1Department of Clinical Pharmacy and Toxicology, VieCuri Medical Center, Venlo, 5912 BL, the Netherlands.
Sexual medicine reviews
|July 21, 2024
概括
这篇综述强调,血清能点最常与终身早泄 (LPE) 有关. 固酶-5抑制剂对LPE治疗有前途,需要进一步研究.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 终身早泄 (LPE) 是早泄的一种亚型,其遗传和治疗发现不一致.
- 以前的研究集中在神经递质如血清素和药物如SSRI,产生混合的结果.
研究的目的:
- 综合审查与LPE相关的神经生物学目标.
- 调查LPE的遗传关联和药物治疗研究.
主要方法:
- 根据PRISMA-ScR指南进行了范围审查.
- 在2023年3月搜索了五个数据库,没有限制.
- 在查和引用跟踪后,包括52项研究 (18项遗传,34项药物治疗).
主要成果:
- 在遗传学和药物治疗研究中,血清能标 (输送器,受体) 最常与LPE有关.
- 遗传学研究显示,多形态的结果是不同的;药物治疗证实了血清激素抗抑郁药的有效性.
- 固酶-5抑制剂 (tadalafil,vardenafil) 也显示出成功的治疗结果.
结论:
- 这是对LPE.第一个全面的范围审查.
- 血清路被强烈认为是LPE的诱导因素.
- 固酶-5抑制剂显示出对LPE治疗的潜力,需要进一步研究;其他标不太可能是贡献者.
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