单核酸多态和糖尿病视网膜病变风险之间的关联:一个总体审查
Shaofen Huang1, Yonghui Feng2, Ying Sun2
1Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518067, China.
Endocrine journal
|July 21, 2024
概括
像TCF7L2 C/T这样的遗传变异绝对与糖尿病视网膜病变 (DR) 风险有关. 虽然IL-6和VEGF多态表现出相关性,但需要进一步的研究来证实它们在DR发展中的作用.
科学领域:
- 遗传学 遗传学 是一个
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 识别遗传因素可以改善DR风险的预测和管理.
- 以前的研究已经探索了与DR相关的各种遗传变异.
研究的目的:
- 进行总体审查,评估遗传变异与糖尿病视网膜病变 (DR) 之间的关联.
- 评估现有的系统审查和关于这个主题的元分析的质量.
- 确定DR发展和进展的确定的遗传风险因素.
主要方法:
- 系统地收集和评估现有的系统审查和元分析.
- 使用AMSTAR 2.0工具进行方法质量评估.
- 使用随机效应模型估计总结效应大小,并计算95%的预测间隔.
- 将证据分为令人信服的,高度暗示的,暗示的,弱的或不显著的.
主要成果:
- 包括32个元分析,涵盖52个候选单核酸多态 (SNP).
- 转录因子7-like 2 C/T (TCF7L2 C/T) 多态 (rs7903146) 显示了令人信服的证据作为DR的危险因素.
- 干白素-6 (IL-6) 和血管内皮生长因子 (VEGF) 多态性显示出与DR风险相关的证据较弱.
结论:
- TCF7L2 C/T 变种是DR发展和进展的决定性遗传风险因素.
- 证据表明IL-6和VEGF多态与DR的关联需要进一步调查.
- 高质量的元分析对于DR中可靠的遗传关联研究至关重要.
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