SIRTIFying

Shweta Tiwary1, Cristina D Guerena1, Jenna L Jewell1

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

概括

瘤抑制剂SIRT4的损失在电离辐射 (IR) 后增加了肠道细胞的增殖. 这是因为细胞更倾向于新核酸合成而不是回收现有核酸.