托芬及其衍生代谢物作为结核病生物标志物:系统性审查
Novi Maulina1,2, Zinatul Hayati2, Kartini Hasballah3
1Doctorate Student of Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23116, Indonesia.
Iranian biomedical journal
|July 22, 2024
概括
托芬 (Trp) 和其代谢物显示出作为检测结核病 (TB) 和监测治疗的非唾液生物标志物的前景. 这些生物标志物,包括二二氧化酶 (IDO) 活性,有效地区分活跃结核病和治疗结果.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 准确的结核病 (TB) 诊断对于病例检测和治疗监测至关重要.
- 托 (Trp) 和其代谢物正在作为结核病潜在的宿主生物标志物进行研究.
研究的目的:
- 评估关于Trp及其代谢物作为结核病检测和治疗监测的生物标志物的现有证据.
- 评估印胺2,3-二氧化酶 (IDO) 活性和相关标记物在结核病诊断中的性能.
主要方法:
- 系统的文献搜索确定了七项相关研究 (2013-2023年).
- 生物标志物的分析,包括IDO活性,IDO-1基因表达和血IDO蛋白.
- 使用的方法:ELISA,LC-MS,UPLC-MS和转录分析.
- 研究包括儿科,成人,孕妇 (TB-HIV) 和多药耐药结核病人群.
主要成果:
- IDO 活性和 IDO 蛋白质水平在将活性结核病与对照区分开来方面表现有前途.
- 这些标志物有效地识别了治疗失败和复发性结核病病例.
- Trp及其代谢物符合活性结核病检测生物标志物的大多数标准.
结论:
- 来自宿主的Trp及其代谢物代表了结核病感染的潜在非脏生物标志物策略.
- 需要进一步验证,以确定Trp代谢物作为可靠的结核病诊断工具.
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