在古姆土著女孩的青春期发育期间皮质醇变化的纵向分析
Delaney J Glass1,2, Jessica Godwin2, Eleanna Bez1
1Department of Anthropology, University of Washington, Seattle, Washington, USA.
概括
皮质醇水平,与压力相关的下丘脑-垂体-上腺轴 (HPA) 的标志物,与女孩青春期的时间存在有限的关联. 高皮质醇可能与早期青春期线性生长的差异有关.
科学领域:
- 内分泌学 在内分泌学.
- 人类成长和发展 人类成长和发展
- 青少年医学 青少年医学
背景情况:
- 青春期研究传统上侧重于下丘脑-垂体-腺轴 (HPG).
- 受压力和皮质醇影响的下丘脑-垂体-上腺轴 (HPA) 越来越被认为是青春期发育中的重要组成部分.
- 皮质醇,青春期时间和线性生长之间的关系需要进一步研究.
研究的目的:
- 在青春期探索年龄,线性生长,脂肪,C- (胰岛素代理) 和皮质醇之间的关系.
- 测试较高的皮质醇水平是否与较早的初潮和峰值高度速度相关.
- 检查HPA轴在青春期成熟中的作用.
主要方法:
- 长度研究使用777个尿样来自46名年龄在7-14岁的女性.
- 使用贝叶斯纵向混合效应模型和联合建模技术.
- 分析的重点是年龄,线性生长 (高度对年龄z-scores),肥胖,C-和皮质醇水平.
主要成果:
- 发现了有限的证据支持HPA轴上调加速青春期时间的假设.
- 一些证据表明,皮质醇水平可能与青春期早期到中期的相对线性生长 (身高对年龄z-scores) 的变化有关.
- 提高HPA功能和更早的青春期发作或进展之间没有确立强烈的联系.
结论:
- 总体假设,HPA轴上调驱动加速青春期时间,这些数据并没有强烈支持.
- 皮质醇的作用似乎更细微,可能会影响线性生长模式,而不是仅仅决定青春期的开始.
- 需要进行进一步的跨学科研究,以了解压力,HPA轴和青春期发育的复杂相互作用.
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