相关实验视频
Updated: Jun 20, 2025

06:41
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
12.5K
为什么儿童无法生存体外膜氧化?
Georgina K Alexander1, Siva P Namachivayam1,2,3,4, Roberto Chiletti1,2,4
1Paediatric Intensive Care Unit, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Journal of paediatrics and child health
|July 22, 2024
概括
身体外膜氧化 (ECMO) 是对重症儿童的一种救生治疗方法. 虽然整体存活率为67%,但了解死亡原因,特别是那些患有并发症的人,对于优化护理至关重要.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 支持心肺血管的支持.
- 医疗技术评估 医疗技术评估
背景情况:
- 身体外膜氧化 (ECMO) 的使用在重症儿童中正在增加,包括那些患有复杂并发症的儿童.
- 了解为什么儿童无法存活ECMO的具体原因对于改善结果至关重要.
- 这项研究解决了有关儿科ECMO患者死亡率的知识差距.
研究的目的:
- 描述接受ECMO的儿童死亡的特征和原因.
- 为了比较患有高风险并发症的儿童ECMO患者的死亡率.
- 评估ECMO存活率在十年的趋势.
主要方法:
- 在2011年至2020年期间接受ECMO治疗的428名儿童 (<18岁) 的回顾性分析.
- 结果的分类:在48小时内死亡,48小时后死亡和出院生存率.
- 在非幸存者中,ECMO退出原因的分类,包括不可恢复的原始状况和神经预后不佳.
主要成果:
- 整体医院存活率到出院为67%,在十年内没有显著变化.
- 大多数死亡发生在ECMO退出后,原因是无法治愈的疾病 (39%) 或预后不佳 (32%的神经,18%复杂疾病).
- 患有遗传综合征 (58%的死亡率) 和恶性瘤 (0%的存活率) 等高风险并发症的儿童的存活率明显较低.
结论:
- 在儿科ECMO中,死亡通常与由于无法恢复的疾病或不良预后而选择性取消支持有关.
- 尽管面临挑战,但患有高风险并发症的儿童在ECMO治疗中显示出生存潜力.
- 这项研究支持ECMO作为选择重症儿童的可行治疗选择,即使是那些患有复杂疾病的儿童.
相关概念视频
Factors Affecting Erythropoiesis
3.2K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.2K
Acute Respiratory Failure-V
129
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
129
Acute Respiratory Failure-II
196
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
196
Factors Affecting Respiration
4.9K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
4.9K
Assessment of Diffusion and Perfusion
966
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
966
Factors Affecting Pulmonary Ventilation
1.3K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.3K

