小细胞肺癌的放射治疗在当前的临床实践指南中
Haiyan Zeng1, Dirk K M De Ruysscher1, Xiao Hu2
1Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Journal of the National Cancer Center
|July 22, 2024
概括
这项系统性审查发现,虽然小细胞肺癌 (SCLC) 主要放射治疗建议在全球指南中相似,但胸部放射治疗 (TRT) 和预防性部辐射 (PCI) 细节存在差异.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 基于证据的医学 基于证据的医学
背景情况:
- 多个国际指南为小细胞肺癌 (SCLC) 提供了放射治疗建议.
- 这些指导方针的变化可能会影响治疗的一致性和患者的结果.
- 需要综合和比较目前的SCLC放射治疗指南.
研究的目的:
- 系统地审查和比较最近全球SCLC治疗指南中的放射治疗建议.
- 确定指导方针开发方法和特定放射治疗策略的相似之处和差异.
- 突出争议的领域和在SCLC指导方针制定中国际合作的潜力.
主要方法:
- 从2018年1月到2021年2月,系统审查英语,中文或荷兰语出版的SCLC指南.
- 在PubMed和医学协会网站上进行的搜索.
- 数据提取和比较的重点是指导方针开发方法和放射治疗建议,包括胸部放射治疗 (TRT) 和预防性部辐射 (PCI).
主要成果:
- 从各个国家确定了11条最新的SCLC指南.
- 大多数指南使用不同的方法评估证据的强度 (SOE) 和建议的强度 (SOR).
- 主要的放射治疗建议在很大程度上是一致的,但在TRT剂量,时间和体积,以及PCI和SBRT的指示和时间以及SBRT的使用方面注意到了差异.
结论:
- 虽然SCLC的核心放射治疗建议显示出全球共识,但TRT和PCI的具体细节存在分歧.
- 重叠的指导方针开发表明了改善国际合作的潜力,以简化努力和资源.
- 建议进一步开展合作工作,特别是在SCLC放射治疗的有争议或不太明确的领域.
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