吸烟,肺气和纤维化之间的联系:一个回顾性队列研究
Liying Zhai1, Haihong Gong1, Wencheng Yu1
1Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
结合性肺纤维化和肺气 (CPFE) 并没有影响间歇性肺病 (ILD) 的预后. 吸烟增加了CPFE风险,但在非CPFE患者中恶化了生存率,突出显示了ILD中复杂的吸烟-肺-纤维化相互作用.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 胸部医学 胸部医学
背景情况:
- 肺经常与间歇性肺病 (ILD) 一起发生,这种疾病称为结合性肺纤维化和肺 (CPFE).
- 了解吸烟,肺气和ILD中的纤维化之间的相互作用对于患者管理至关重要.
研究的目的:
- 在被诊断患有间歇性肺病的患者中调查吸烟,肺气和纤维化之间的关联.
- 评估CPFE和吸烟状态对ILD患者存活率的预后影响.
主要方法:
- 对800名住院的ILD患者进行了回顾性队列研究.
- 根据吸烟状况分层的CPFE和非CPFE组之间的临床,放射和实验室发现的比较.
- 卡普兰-梅尔生存分析和多变量考克斯回归用于死亡率评估.
主要成果:
- 吸烟与发展CPFE的几率增加了2.13倍.
- 与非CPFE患者相比,CPFE患者的死亡风险与非CPFE患者相似 (AHR=0.89).
- 吸烟对整体ILD或CPFE组的预后没有显著影响,但与非CPFE患者的生存率更差相关 (AHR=1.62).
结论:
- 结合性肺纤维化和肺气 (CPFE) 不会改变间歇性肺病 (ILD) 的整体预后.
- 吸烟是CPFE的风险因素,但不是CPFE患者死亡率的预后因素.
- 吸烟与较差的生存结果有关,特别是在ILD患者的非CPFE亚组中,这表明了复杂的关系.
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