在经过皮肤冠状动脉干预的晚期慢性病患者中出现较高的术后出血
Mohammad Reza Movahed1,2, Sina Aghdasi1, Mehrtash Hashemzadeh2
1University of Arizona Sarver Heart Center, College of Medicine Tucson, AZ, USA.
American journal of blood research
|July 22, 2024
概括
经过皮肤冠状动脉干预 (PCI) 的晚期慢性病 (ACKD) 患者面临更高的出血风险. 这项研究证实,ACKD独立地增加了PCI后出血并发症,即使整体率下降.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床研究 临床研究
背景情况:
- 晚期慢性病 (ACKD) 在接受皮肤冠状动脉干预 (PCI) 的患者中很普遍.
- PCI后出血是死亡率的重要预测因素,在ACKD患者中构成挑战.
- 现有的研究往往排除了ACKD患者,限制了对其特定风险的理解.
研究的目的:
- 调查ACKD和PCI后出血并发症之间的关联.
- 为了比较ACKD患者的出血率与没有ACKD的患者进行PCI.
主要方法:
- 2006-2011年国家住院样本 (NIS) 数据库的分析.
- 包括40岁以上接受PCI的患者,使用ICD-9 CM代码进行识别.
- 在ACKD (CKD阶段3+) 和对照组之间,PCI后出血率的比较.
主要成果:
- 在49192名PCI后出血的患者中,7.5%患有ACKD.
- ACKD患者年龄较大 (平均年龄为68.7岁).
- 在多变量调整后,ACKD独立与PCI后出血风险增加有关 (OR:1.07,CI:1.03-1.11,P<0.001).
结论:
- 晚期慢性病是PCI后出血的一个独立风险因素.
- 尽管出血率普遍下降,但ACKD患者的风险仍然较高.
- 对接受PCI的ACKD患者进行进一步的研究和风险减轻策略是有必要的.
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