欧米克朗变种和肺部卷入:无症状和轻度COVID-19患者的胸部成像分析
Peiben Liu1,2, Kejun Cao2, Guanqun Dai3
1Department of Critical Care Medicine, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Frontiers in public health
|July 22, 2024
概括
在无症状和轻度症状的SARS-CoV-2 Omicron变种感染中,肺部参与是常见的. 年龄,长时间的负转换时间和先前存在的肺部疾病是明显肺部参与的关键风险因素.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 在全球范围内,SARS-CoV-2 Omicron 变种已经占主导地位.
- 在无症状或轻度症状的病例中,肺部参与需要进一步调查.
- 胸部成像在评估肺部健康方面发挥着至关重要的作用.
研究的目的:
- 确定SARS-CoV-2 Omicron变种感染的无症状和轻度症状患者肺部感染的临床特征和危险因素.
- 分析与肺部疾病相关的胸部计算机断层扫描 (CT) 成像特征.
- 为明显的肺部干扰 (OPI) 开发一个预测模型.
主要方法:
- 对339名无症状/轻度症状的Omicron感染患者的胸部CT成像和临床数据的回顾性分析.
- 对CT成像特征的评分,将患者分为OPI (评分>2) 和不明显的肺部干扰 (NOPI) (评分 ≤2) 组.
- 后勤回归和名录图可视化以确定OPI的独立风险因素.
主要成果:
- 咳是最常见的症状 (75.5%);线性不透明度是最常见的CT发现 (42.8%).
- 肺部干扰在左下肺叶更为普遍.
- OPI的独立风险因素包括年龄分层 (OR=1.92),长时间的核酸负转换时间 (NCT>8d) (OR=1.842),以及先前存在的肺部疾病 (OR=4.698).
结论:
- 无症状和轻度症状患者感染Omicron变种的肺部感染并不罕见.
- 年龄,长期NCT和肺部疾病是OPI的重要预测因素.
- 这些发现有助于临床医生识别高风险患者进行早期干预.
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