在假定/确认的耐药结核病中,NTM的流行率和预测因素
E T Abbew1,2,3, R Laryea4, F Sorvor5
1Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
IJTLD open
|July 22, 2024
概括
非结核菌 (NTM) 经常在加纳的耐药结核病 (DR-TB) 患者中发现. * Mycobacterium intracellulare * 是最常见的NTM物种,随访样本增加了NTM隔离率.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 非结核菌 (NTM) 越来越多地与假定/确认的肺结核 (TB) 一起被分离出来.
- 了解耐药结核病 (DR-TB) 种群中的NTM流行率和物种分布对于有效管理至关重要.
研究的目的:
- 估计在加纳被认为/确认的DR-TB的个体中NTM的流行率和物种分布.
- 在这个人群中确定与NTM隔离相关的预测因素.
主要方法:
- 对2012-2021年DR-TB诊断和随访的唾液样本进行了回顾性分析.
- 菌根菌培养,MPT64分化试验,以及使用GenoType®和测序 (16S rRNA,rpoB) 的物种鉴定.
- 后勤回归分析以确定NTM隔离的预测因素.
主要成果:
- 在2,492个样本中,33.7%为培养阳性;30.6%被认为是NTM.
- 证实了物种鉴定 *Mycobacterium intracellulare *作为主要的NTM (66.0%).
- 在随访样本中观察到NTM隔离的几率增加 (aOR 2.41). 四名患者患有NTM肺部疾病.
结论:
- 在加纳的DR-TB患者中,NTM隔离是一个重要的发现.
- 更好地了解当地的NTM流行病学和诊断对于优化患者护理和结果至关重要.
相关概念视频
Pulmonary Tuberculosis V
177
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
177
Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
Pulmonary Tuberculosis I
228
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
228
Pulmonary Tuberculosis III
317
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
317
Pulmonary Tuberculosis II
215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215


