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Updated: Jun 20, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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使用生理学基础的药理动力学建模来获得正确的剂量:德克萨米他以防止在儿童中排泄后的斯特里多,作为概念证明

Joyce E M van der Heijden1, Marika de Hoop-Sommen1, Noa Hoevenaars1

  • 1Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.

Frontiers in pediatrics
|July 22, 2024
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模可以优化德克萨米他的剂量,用于预防儿科的输出管后肌痛 (PES). 适合年龄的PBPK模型显示,对于婴儿和年龄较大的儿童,需要降低德甲剂量,从而改善药物处置.

关键词:
德克萨米他是一种建模和模拟模型和模拟儿科 儿科 儿科 儿科药物动力学 药物动力学基于生理学的药物动力学建模.特殊种群的特殊种群.

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