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模拟使用预防性过敏原标签的门:对患病率和风险的影响
Kamila Lizée1, Silvia Dominguez1, Jérémie Théolier1
1Food Risk Analysis and Regulatory Excellence Platform (PARERA), Institute of Nutrition and Functional Foods and Department of Food Science, Université Laval, Quebec, Quebec, G1V 0A6, Canada.
Heliyon
|July 22, 2024
概括
实施对食品的预防性过敏原标签 (PAL) 的过敏原值准则可以显著减少食物过敏 (FA) 反应. 对PAL的门驱动方法可能为FA患者提供更好的风险沟通和安全.
科学领域:
- 食品安全 食品安全
- 过敏原风险评估评估过敏原风险评估
- 公共卫生营养 公共卫生营养
背景情况:
- 预包装食品上的预防性过敏原标签 (PAL) 应用不一致,降低了其在传播食物过敏 (FA) 风险方面的有效性.
- 专家建议使用PAL的过敏原度值,但这种方法尚未得到广泛采用.
研究的目的:
- 根据科学得出的过敏原度值,对应用PAL的影响进行定量评估.
- 为了比较当前PAL实践的风险沟通效率与加拿大FA患者的基于值的方法.
主要方法:
- 蒙特卡洛风险模拟被用于模拟食物消费场景.
- 在两个场景下分析了四种过敏原和九种食品类别:当前的PAL使用和基于值的假设PAL.
- 模拟考虑了保护99% (ED01) 和95% (ED05) 的FA个体的门,以及消费者避免PAL产品.
主要成果:
- 加拿大目前的PAL实践显示了潜在反应的高变化,牛奶交叉接触带来了最大的风险 (高达1120次反应/10,000次进食).
- 基于值的假设PAL方法 (ED01) 可以将反应限制在最多15/10,000次的饮食中.
- 没有PAL的产品,在基于值的系统下,与目前的PAL产品相比,通常会导致较少的不良反应.
结论:
- 在预包装食品中采用PAL的门驱动方法可以提高FA患者的安全性.
- 基于定义过敏原值的PAL实施,加上消费者指导,可能会导致显著减少和减轻过敏反应.
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