艾滋病毒感染者肥胖现象的心脏代谢特征
Alison Z Swartz1, Michelle E Robles2, Seungweon Park1
1School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Open forum infectious diseases
|July 22, 2024
概括
艾滋病毒感染者的肥胖表型 (PWH) 存在超出BMI的独特风险. 识别这些特定的肥胖类型对于个性化护理和控制心脏代谢疾病风险至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 脂肪组织储存与一般人群中的心脏代谢疾病风险有关.
- 肥胖,艾滋病毒和抗逆转录病毒疗法 (ART) 相互作用增加了艾滋病毒感染者 (PWH) 的风险.
- 肥胖异质性需要确定个性化PWH护理的特定表型.
研究的目的:
- 确定艾滋病毒感染者 (PWH) 中不同肥胖现象型的流行率和特征.
- 为了确定与每种肥胖表型相关的特定风险因素,在PWH.
- 为个人化风险分层和PWH治疗优化提供信息.
主要方法:
- 计算机断层扫描 (CT) 在L3脊椎的扫描细分,以定义内脏,骨,骨髓,肝骨质和代谢健康的肥胖症.
- 多变量线性回归模型分析了人类学,临床生物标志物和炎症因素.
- 对年龄,性别,种族和体重指数 (BMI) 进行控制的模型.
主要成果:
- 在187名PWH中,普遍存在的表型包括内脏 (59%),骨髓 (25%),代谢健康 (32%),肉性 (11%),肝骨髓性 (9%) 肥胖.
- 高甘油:HDL比率预测了内脏肥胖;皮下脂肪和HDL增加预测了sarcopenic肥胖.
- 糖尿病,IL-6和HDL预测了肌骨发育性肥胖;增加的CD4+计数预测了肝骨发育性肥胖.
结论:
- 离散的肥胖现象在PWH中很常见,并带有不仅仅通过BMI捕捉到的风险.
- 这些表型具有不同的预测因子,包括代谢,炎症和免疫标志物.
- 研究结果支持使用肥胖现象型用于PWH风险分层和个性化治疗.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒心脏代谢疾病心脏代谢疾病骨髓骨质炎 (myosteatosis) 是一种疾病.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖现象型 现象型 是一种现象型.这种类型的麻症是sarcopenia.更多相关视频
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