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Updated: Jun 20, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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了解重症患者的抗微生物药物动力学,以优化抗微生物治疗:一个叙事性审查

Claire Roger1,2

  • 1Department of Anesthesiology and Intensive Care, Pain and Emergency Medicine, Nîmes-Caremeau University Hospital, Nîmes, France.

Journal of intensive medicine
|July 22, 2024
PubMed
概括

在败血症中优化抗菌剂量对患者的生存至关重要. 本综述详细介绍了当治疗药物监测不可用时,如何在重症患者中调整抗生素剂量.

关键词:
抗生素 抗生素是一种抗生素.剂量优化的优化在ICU中,医生会对患者进行治疗.药理动力学/药理动力学在TDM TDM中使用.

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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method12:03

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Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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However, dosage adjustments...
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Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
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