经过14年性腺激素治疗后的侵袭性前列腺癌:一个病例报告
Fumie Yoshioka1, Hiroshi Kiuchi1, Testuji Soda1
1Department of Urology, Osaka Central Hospital, Osaka, JPN.
Cureus
|July 22, 2024
概括
使用淋巴激素治疗低激素性低激素症并没有增加前列腺癌风险. 然而,低丸激素患者可能会患上晚期前列腺癌,需要定期进行前列腺特异性抗原 (PSA) 监测.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 低性激素水平的特征是低性激素水平低,导致不孕.
- 淋巴激素疗法是治疗低阴性淋巴激素的标准治疗方法.
- 丸激素水平和前列腺癌风险之间的关系是复杂的,需要进一步调查.
研究的目的:
- 报告一个先进的前列腺癌病例,该病例发生在患者中,该患者有过治疗性腺激素的前列腺低激素性低激素主义史.
- 突出定期前列腺特异性抗原 (PSA) 监测在患有低阴腺特异性低阴腺症的患者中的重要性,即使是在淋巴激素治疗期间和之后.
主要方法:
- 一个40岁男性的病例报告,患有低阴性腺和不孕症.
- 开始淋巴激素治疗并随后在20年内对血清PSA水平进行监测.
- 晚期前列腺癌的诊断通过活检,骨扫描和PSA进展得到确认.
- 用抗雄激素剥夺疗法,恩扎胺和-223化物进行治疗.
主要成果:
- 患者在停止淋巴激素治疗20年后发展为晚期前列腺癌 (格里森得分4+5,cT4N0M1b).
- 抗原PSA水平显示出延迟但显著的增加,最终达到65.9 ng/mL.
- 用恩扎胺和-223的治疗导致骨转移和PSA水平的减少.
结论:
- 虽然淋巴激素治疗可能不会直接增加前列腺癌的风险,但患有潜在低水平的患者容易患上高级,晚期前列腺癌.
- 持续监测PSA水平,即使低于4ng/mL,对于这些患者的前列腺癌早期检测至关重要.
- 对持续升高的PSA水平进行及时调查是有必要的,以排除恶性瘤.
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