抗生素耐药性在尿路感染的模式:一个回顾性观察性研究
Nitheesha Reddy Marepalli1, Aneesh Rao Nadipelli2, Rahul Jain Manohar Kumar Jain3
1Department of Internal Medicine, Dr. Patnam Mahender Reddy Institute of Medical Sciences, Hyderabad, IND.
Cureus
|July 22, 2024
概括
尿路感染 (UTI) 抗生素耐药性正在增加. 尼特洛黄因具有较低的抗性,对尿路感染有效,而诺基诺抗性需要更新局部治疗指南.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 尿路感染 (UTI) 是一种常见的细菌感染.
- 抗生素耐药性对尿路感染的有效实证治疗构成重大挑战.
- 优化经验性尿路感染管理需要了解当前的局部抵抗模式.
研究的目的:
- 描述导致尿路感染的尿病原体中最近的抗生素耐药性模式.
- 在第三级护理环境中为尿路感染提供信息并优化实证治疗策略.
主要方法:
- 在2023年6月至11月期间对280名尿路感染患者进行了回顾性观察研究.
- 来自电子医疗记录的尿液培养和抗生素敏感性数据的分析.
- 包括患者的人口统计,致病性尿病原体,耐药率和治疗结果.
主要成果:
- 最常见的尿路病原体是大肠杆菌 (75%) 和肺炎菌 (15%).
- 观察到对安皮西林和西普罗夫洛克萨的高耐药率,特别是在K. pneumoniae中.
- 尼托福兰因表现出较低的耐药性率 (大肠杆菌为*5%,肺炎为*22%) 并经常被处方 (45%).
结论:
- 诺基诺抗性的增加强调了需要更新的局部数据来指导经验性尿路感染治疗的必要性.
- 尼托福兰因 (Nitrofurantoin) 成为一种有效的第一线药物,具有较低的抗性.
- 对尿路感染耐药性模式的持续监测对于优化抗生素选择至关重要.
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