身体活动和肺癌风险:对队列研究的系统审查和剂量反应元分析
Ranran Qie1, Minghui Han2, Huang Huang1
1Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of the National Cancer Center
|July 22, 2024
概括
参与总体体育活动 (TPA) 和休时间体育活动 (LTPA) 可以降低肺癌的风险. 在LTPA和肺癌之间存在U形的关联,在每周15个MET小时观察到的最佳益处.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 身体活动对整体健康至关重要.
- 不同类型的体育活动与肺癌风险之间的关系需要进一步澄清.
- 现有的研究对身体活动对肺癌的影响提出了不同的结论.
研究的目的:
- 综合目前关于总体体育活动 (TPA),休时间体育活动 (LTPA) 和职业体育活动 (OPA) 与肺癌风险之间的关联的证据.
- 调查LTPA水平与肺癌发病率之间的剂量反应关系.
- 提供身体活动在预防肺癌中的作用的全面概述.
主要方法:
- 在PubMed和Web of Science进行了系统的文献搜索,截至2021年11月.
- 使用包括随机效应或固定效应模型在内的元分析技术来计算总结相对风险 (RR) 和95%置信区间 (CI).
- 限制立方线被用于剂量反应分析,以探索LTPA和肺癌风险之间的关系.
主要成果:
- 该元分析包括25篇文章,包括42项队列研究,其中9,983,295名参与者和85,988例肺癌病例.
- 高水平的TPA和LTPA与肺癌风险降低有关 (分别降低22%和12%).
- 在LTPA和肺癌风险之间观察到显著的U形关联,风险最低为每周15个MET小时. 与坐着的职业相比,失业者和站立的职业群体的肺癌风险增加.
结论:
- 总体体育活动 (TPA) 和休时间体育活动 (LTPA) 表明对肺癌有保护作用.
- 在这次元分析中,职业体力活动 (OPA) 与肺癌风险没有显著的关联.
- 确定的LTPA与肺癌风险之间的U形关联突出显示了潜在的最佳活动水平来降低风险,并需要进一步调查.
相关概念视频
Statistical Methods for Analyzing Epidemiological Data
344
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
344
Observational Studies
8.4K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
8.4K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
COPD: Management Using Bronchodilators and Corticosteroids
193
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
193
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Criteria for Causality: Bradford Hill Criteria - II
272
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
272


