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Updated: Jun 20, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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瘤突变负担被目标癌症基因小组高估了

Hu Fang1,2, Johanna Bertl3, Xiaoqiang Zhu1

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Journal of the National Cancer Center
|July 22, 2024
PubMed
概括

癌症基因组经常高估瘤突变负担 (TMB),可能错误地将患者分类为免疫检查点抑制剂 (ICI). 一个新的统计模型纠正了整个外体和面板数据之间的TMB差异,改善了ICI治疗的患者分层.

关键词:
生物标志物生物标志物免疫检查点抑制剂 免疫检查点抑制剂免疫反应的免疫反应.瘤突变负担的突变负担

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