抗氧化作用的α-托科菲罗尔在存储的人类红细胞单位
Saeideh Hajizamani1, Kamran Atarodi1, Mohammad Reza Deyhim1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Asian journal of transfusion science
|July 22, 2024
概括
阿尔法托科菲罗尔补充剂通过减少氧化应激和血液溶解来改善红细胞 (RBC) 质量. 在储存期间,最高度 (3.125毫米) 显示出最显著的抗氧化作用.
科学领域:
- 血液银行和输血医疗服务
- 生物化学和氧化应激作用
- 抗氧化剂研究的研究.
背景情况:
- 红细胞 (RBC) 储存导致生物化学变化,称为储存损伤.
- 氧化应激有助于红细胞降解,影响输血疗效.
- 抗氧化剂阿尔法托科菲罗尔可以减轻这些储存引起的变化.
研究的目的:
- 为了评估保存的红细胞单位中的α-托科菲罗尔的抗氧化疗效.
- 为了确定不同度的α-托哥菲罗尔对红细胞质量标志物的影响.
- 评估alpha-tocopherol在红细胞储存期间对氧化应激和血液溶解的影响.
主要方法:
- 红细胞单元 (CPDA1) 被分为卫星袋,并补充了不同度的α-托哥法醇 (0.125,0.625,3.125毫米) 或乙醇 (控制).
- 单位在1-6°C下存储35天.
- 定期测量马隆迪甲基 (MDA),总抗氧化能力 (TAC) 和血液溶解指数 (HI).
主要成果:
- 在35天内,MDA度和HI增加,而TAC在所有组都下降 (P<0.05).
- 与对照组相比,3.125mM的α-托科菲罗尔组显示MDA和HI的增加明显较低.
- 与对照组相比,阿尔法托科菲罗尔补充剂在试验组显著增加了TAC,而储存期间的水平下降较小.
结论:
- 阿尔法托科菲罗尔补充剂通过减少脂质过氧化和血液溶解来提高红细胞单位的质量.
- 它还增加了在红细胞储存期间的总抗氧化能力.
- 度为3.125毫米的α-托科菲罗尔显示出最强大的抗氧化作用.
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