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在自愿献血者中,COVID-19的血清流行率

Arumugam Pothipillai¹, Swathandran Hamsavardhini¹, Deepa Duraisamy¹

¹Department of Transfusion Medicine, The Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.

Asian journal of transfusion science

|July 22, 2024

概括

一项研究发现无症状的献血者中高SARS-CoV-2 (COVID-19) IgG抗体血清流行率 (58.8%). IgM + IgA 血清流行率为 29.6%,表明尽管有轻微的症状,但先前感染已经广泛传播.

科学领域:

输血医学输血医学
病毒学病毒学
免疫学免疫学免疫学

背景情况:

COVID-19通常会引起轻微的症状,输血传播很罕见.
在献血者中评估病毒感染的流行率对于血液安全至关重要.
之前没有关于输血传播的COVID-19的报道.

研究的目的:

在健康,无症状的自愿献血者中确定SARS-CoV-2抗体的血清流行率.
使用酶相关免疫吸收试验 (ELISA) 来检测抗体.

主要方法:

在18个月内对500名无症状,未接种疫苗的自愿献血者进行了一项横截面研究.
血液样本使用ELISA检测SARS-CoV-2的IgG,IgM和IgA抗体.
统计分析包括皮尔森的奇平方和费舍尔的精确测试.

主要成果:

IgG 血清阳性为58.8%,IgM + IgA 血清阳性为29.6%.
根据年龄,性别,血型,职业或社会经济地位,没有发现血清阳性显著差异.
仅使用IgG的ELISA套件,由于敏感性更高,血清流行率增加了3%.

结论:

在无症状的献血者中,很大一部分人表现出了SARS-CoV-2 IgG或IgM + IgA抗体.
观察到的血清阳性率与人口水平的COVID-19激增相关.
这些发现强调了在献血者群体中监测无症状感染的重要性.

关键词:

在 COVID-19 疫情中,血清发生率的普遍性.志愿献血者是自愿献血的人.

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