帕纳克斯物种及其生物活性成分对过敏呼吸道疾病的影响
Dahee Shim1, Yeeun Bak2, Han-Gyu Choi3
1Industry-Academic Cooperation Foundation, Hallym University, Chuncheon, Republic of Korea.
Journal of ginseng research
|July 22, 2024
概括
帕纳克斯种,富含金氏化物,显示在治疗喘和鼻炎等过敏呼吸道疾病 (AADs) 的潜力. 它们的生物活性成分调节免疫反应,减少炎症,提供有前途的治疗途径.
科学领域:
- 药理学和免疫学 药理学和免疫学
- 自然产品化学 自然产品化学
- 过敏和呼吸系统医学
背景情况:
- 过敏性呼吸道疾病 (AAD),包括过敏性喘 (AA) 和过敏性鼻炎 (AR),涉及上皮损伤和Th2-歪曲的免疫反应.
- 在AAD中激活的巨细胞和基细胞释放组胺和白血,加剧炎症.
- 帕纳克斯物种含有生物活性成分 (BCs),如具有已知的药理活性的金赛诺化物和多糖类.
研究的目的:
- 审查Panax物种及其BCs对AADs的免疫调节和抗炎作用.
- 总结Panax BCs与免疫细胞和上皮细胞相互作用的机制.
- 突出Panax物种对过敏性喘和过敏性鼻炎的治疗潜力.
主要方法:
- 对Panax物种及其生物活性成分的体外和体内研究的文献综述.
- 分析涉及树突细胞-T细胞相互作用,上皮细胞反应和巨细胞/基细胞活动的机制.
- 在过敏呼吸道疾病的临床前模型中评估Panax物种疗效的证据.
主要成果:
- 帕纳克斯物种及其BCs通过影响树突细胞和T细胞相互作用来调节获得的免疫反应.
- 这些化合物降低了上皮细胞的亲炎性反应,并减轻了来自巨细胞和基细胞的过敏反应.
- 在体内研究表明,Panax物种及其BC对过敏性喘和过敏性鼻炎的缓解作用.
结论:
- 帕纳克斯物种及其生物活性成分具有治疗过敏呼吸道疾病的巨大潜力.
- 需要进一步的研究来阐明具体的机制,并优化患者治疗的治疗策略.
- 这一审查为开发Panax衍生治疗过敏性喘和过敏性鼻炎提供了科学基础.
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