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Updated: Jun 20, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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染色体组装因子1抑制了对适应性耐药性的表观遗传重编程

Zhiquan Wang1, Rentian Wu1, Qian Nie1

  • 1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

Journal of the National Cancer Center
|July 22, 2024
PubMed
概括

在黑色素瘤中,向癌症治疗的耐药性涉及表观遗传变化. 恢复素H3氨酸9三甲基化 (H3K9me3) 可能通过向染色体组合因子1 (CAF-1) 来克服对BRAF抑制剂的耐药性.

关键词:
适应性耐药性是一种适应性耐药性.这是一种BRAF抑制剂.染色体组合因子1 染色体组合因子1表观遗传重编程是一种表观遗传重编程.H3K9me3是什么意思 H3K9me3是什么意思核组合组合的核组合.有针对性的治疗.

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