脑卒中后认知障碍的危险因素:一个元分析
Jinyu Wang1, Guangyu Cheng, Yuanyuan Yang2
1Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Vascular and endovascular surgery
|July 22, 2024
概括
脑卒中后认知障碍 (PSCI) 在老年人,女性或受教育程度较低的人群中更有可能发生. 关键的危险因素包括高血压,糖尿病,心房动和以前的中风史.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 老年病的医生 老年病的医生
背景情况:
- 脑卒中后认知障碍 (PSCI) 是中风的常见和使人虚弱的后果.
- 识别PSCI的风险因素对于制定有效的预防和管理策略至关重要.
研究的目的:
- 进行全面的元分析,以确定与中风后认知障碍 (PSCI) 发展相关的重大风险因素.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,CNKI) 进行了系统的文献搜索.
- 包含的研究的质量评估是使用Cochrane ROB工具进行的.
- 进行了数据提取和异质性评估 (I2,P值),随后对聚合估计进行了随机或固定效应建模.
- 使用漏斗图和埃格尔测试来评估出版偏差,并进行灵敏度分析以确保稳定性.
主要成果:
- 分析包括23项研究,涉及13,322名患者.
- 老年人 (汇总MD = 3.58),女性 (汇总RR = 1.23) 和受教育程度较低的人 (汇总MD = -1.63) 患PSCI的风险更高.
- 患有高血压史 (合并RR=1.07),糖尿病 (合并RR=1.10),心房动 (合并RR=1.38),以及先前的中风 (合并RR=1.36) 是显著的危险因素.
- 吸烟与PSCI发展没有显著的关联 (合并RR = .96).
结论:
- 年龄,女性性别,较低的教育水平,高血压,糖尿病,心房动和中风病史是PSCI的确诊危险因素.
- 针对控制这些已识别的风险因素的有针对性的干预措施可能有助于预防中风后认知障碍.
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