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相关概念视频

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: May 5, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
06:47

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression

Published on: July 30, 2015

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甲状腺上皮器官介导T细胞的发育.

Tania Hübscher1, L Francisco Lorenzo-Martín1, Thomas Barthlott2

  • 1Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Development (Cambridge, England)
|July 22, 2024
PubMed
概括
此摘要是机器生成的。

研究人员开发了胸腺器官,用于研究T细胞发育. 这些有机体在体外模仿胸腺,支持生理T细胞的发育,为研究和再生策略提供新的途径.

关键词:
鼠标 鼠标是一个鼠标.器官类动物 器官类动物在T细胞,T细胞.胸膜上皮细胞 胸膜上皮细胞甲状腺发育 甲状腺发育甲状腺腺体是什么意思

更多相关视频

Preparation and Applications of Organotypic Thymic Slice Cultures
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Preparation and Applications of Organotypic Thymic Slice Cultures

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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

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相关实验视频

Last Updated: May 5, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
06:47

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression

Published on: July 30, 2015

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Preparation and Applications of Organotypic Thymic Slice Cultures
10:10

Preparation and Applications of Organotypic Thymic Slice Cultures

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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
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Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

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科学领域:

  • 免疫学 免疫学 免疫学
  • 发展生物学 发展生物学
  • 再生医学是一种再生医学.

背景情况:

  • 有机体对研究有很大的潜力,但与免疫系统相关的有机体还不发达.
  • 胸腺是T细胞发育的关键淋巴体器官.

研究的目的:

  • 为了从胸腺中建立功能性有机体.
  • 研究这些有机体在体外研究T细胞发育和胸膜上皮细胞 (TEC) 生物学方面的潜力.

主要方法:

  • 发展了小鼠胸部上皮原生细胞扩散成有机体的条件.
  • 具有特征的有机细胞种群和转录形状.
  • 再聚合的有机体与T细胞祖先来评估功能.

主要成果:

  • 产生的胸膜上皮有机体具有多样化的细胞群体,在体内类似于TECs.
  • 在体外 (in vitro) 中,有机体维持了胸腺功能,并支持了生理T细胞的发育.
  • 反聚合物在体内表现出类似表皮的多样性和原生细胞吸引力.

结论:

  • 胸膜上皮有机体是来自淋巴体器官膜区的第一个有机体.
  • 这些有机体为研究TEC生物学和T细胞发育提供了一个新的平台.
  • 这项工作为治疗衰老或受伤的胸膜再生策略铺平了道路.