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相关概念视频

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

4.8K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

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Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
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Solvents01:12

Solvents

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A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
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Amines to Sulfonamides: The Hinsberg Test01:23

Amines to Sulfonamides: The Hinsberg Test

3.3K
The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing...
3.3K

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Preparation of Binary and Ternary Deep Eutectic Systems
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可切换的深度阳性溶剂,用于可持续的硫胺合成.

Maristella Simone1, Mara Pulpito1, Filippo Maria Perna1

  • 1Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, Bari, I-70125, Italy.

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概括

这项研究引入了一种绿色合成硫胺,使用基于胆化的深度环氧溶剂. 这种可持续的方法在环境温度下提供了高产量,证明了它对制药中间体的实用性.

关键词:
氨基酸是氨基酸中的一种.深层欧性溶剂 深层欧性溶剂硫胺是什么 硫胺是什么硫基化物 硫基化物可持续的化学可持续的化学

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科学领域:

  • 绿色化学 绿色化学
  • 有机合成 有机合成
  • 溶剂工程 溶剂工程

背景情况:

  • 硫胺在制药中至关重要.
  • 传统的合成方法通常涉及恶劣的条件和危险的试剂.
  • 开发可持续和高效的合成协议至关重要.

研究的目的:

  • 开发一种可持续和可扩展的协议,用于合成功能化的硫胺.
  • 利用对环境负责任且可重复使用的深层水溶剂 (DES).
  • 为了证明该协议在合成制药中间体中的适用性.

主要方法:

  • 使用基于胆化物 (ChCl) 的DES,特别是ChCl/甘油和ChCl/尿素混合物.
  • 在空气条件下,在环境温度下,在氨基和硫基化物之间进行反应.
  • 使用诸如E-factor和EcoScale这样的定量指标来评估环保性.

主要成果:

  • 对各种功能化的硫胺类物质实现了高产率 (高达97%).
  • 在温和条件下,在2-12小时内成功合成.
  • 成功合成了一种FFA4激动剂和抗阿尔茨海默症药物BMS-299897的前体.
  • 展示的产品通过简单的提取或过经过装后进行隔离.

结论:

  • 基于胆化的DES为硫胺合成提供了可持续和高效的介质.
  • 该协议具有可扩展性,环保性和实用性,用于合成有价值的化合物.
  • 开发的方法为传统的硫胺合成途径提供了更绿色的替代方案.