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Updated: Jun 20, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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最近的工具箱用于蛋白质的化学选择性双重修饰

Yiping Zhao1, Tianmeng Zhang2, Yujie Zhu2

  • 1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China.

Chemistry (Weinheim an der Bergstrasse, Germany)
|July 22, 2024
PubMed
概括

选择性蛋白质修饰使得精确的蛋白质工程能够用于治疗和研究. 双重功能化策略正在快速发展,提供超出单个修改的增强蛋白质特性.

关键词:
生物对等化学的化学.蛋白质的双重修饰.酶 是一种酶.多功能化的多功能化.非天然的氨基酸.

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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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